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Article

Performance of epistasis detection methods in semi-simulated GWAS.

BMC bioinformatics - 18 Jun 2018

Chatelain Clément, Durand Guillermo, Thuillier Vincent, Augé Franck

Abstract excerpt

BACKGROUND: Part of the missing heritability in Genome Wide Association Studies (GWAS) is expected to be explained by interactions between genetic variants, also called epistasis. Various statistical methods have been developed to detect epistasis in case-control GWAS. These methods face major statistical challenges due to the number of tests required, the complexity of the Linkage Disequilibrium (LD) structure,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29914375
DOI: 10.1186/s12859-018-2229-8
PMCID: PMC6006572

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