Article
Parallel and serial computing tools for testing single-locus and epistatic SNP effects of quantitative traits in genome-wide association studies.
BMC bioinformatics - 21 Jul 2008
Ma Li, Runesha H Birali, Dvorkin Daniel, Garbe John R, Da Yang
Abstract excerpt
BACKGROUND: Genome-wide association studies (GWAS) using single nucleotide polymorphism (SNP) markers provide opportunities to detect epistatic SNPs associated with quantitative traits and to detect the exact mode of an epistasis effect. Computational difficulty is the main bottleneck for epistasis testing in large scale GWAS. RESULTS: The EPISNPmpi and EPISNP computer programs were developed for testing...
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