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Article

EpiGEN: an epistasis simulation pipeline.

Bioinformatics (Oxford, England) - 8 Dec 2020

Blumenthal David B, Viola Lorenzo, List Markus, Baumbach Jan, Tieri Paolo, Kacprowski Tim

Abstract excerpt

SUMMARY: Simulated data are crucial for evaluating epistasis detection tools in genome-wide association studies. Existing simulators are limited, as they do not account for linkage disequilibrium (LD), support limited interaction models of single nucleotide polymorphisms (SNPs) and only dichotomous phenotypes or depend on proprietary software. In contrast, EpiGEN supports SNP interactions of arbitrary order,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32289146
DOI: 10.1093/bioinformatics/btaa245

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