Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional genetic variation of the 5-HTR2A receptor affects age at onset in patients with temporal lobe epilepsy.

Annals of human genetics - 1 Jul 2012

Manna Ida, Labate Angelo, Mumoli Laura, Palamara Grazia, Ferlazzo Edoardo, Aguglia Umberto, Quattrone Aldo, Gambardella Antonio

Abstract excerpt

The 1354C>T polymorphism of the 5-hydroxytryptamine receptor 2A gene (5-HTR2A) was implicated in human memory performance. We investigated the relationship between this polymorphism and cognitive function in patients with temporal lobe epilepsy (TLE). We also evaluated if this polymorphism could influence the phenotype. There were 138 patients with TLE: 25% (34/138) of them found to be cognitively impaired, while...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Age of Onset

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Aged, 80 and over

Share to Epilepsy, Temporal Lobe

Share to Memory

Share to Polymorphism, Genetic

Share to Receptor, Serotonin, 5-HT2A

Share to Young Adult

Source

Identifiers

PMID: 22681516
DOI: 10.1111/j.1469-1809.2012.00713.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional genetic variation of the 5-HTR2A receptor affects age at onset in patients with temporal lobe epilepsy.PMID 22681516Read ↗

Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.Semantic proximity Read ↗

A functional genetic variation of the 5-HT2a receptor affects human memory.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) gene polymorphisms and psychiatric comorbidities in temporal lobe epilepsy.Semantic proximity Read ↗

SLC6A4 gene variants and temporal lobe epilepsy susceptibility: a meta-analysis.Semantic proximity Read ↗

GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: new evidence.Semantic proximity Read ↗

NTRK2 (TrkB gene) variants and temporal lobe epilepsy: A genetic association study.Semantic proximity Read ↗

ApoE epsilon4 genotype and the age at onset of temporal lobe epilepsy: a case-control study and meta-analysis.Semantic proximity Read ↗

G protein beta3 subunit C825T polymorphism modifies the presentation of temporal lobe epilepsy.Semantic proximity Read ↗

Influence of serotonin receptor 2A His452Tyr polymorphism on brain temporal structures: a volumetric MR study.Semantic proximity Read ↗

Epilepsy and serotonin (5HT): variations of 5HT-related genes in temporal lobe epilepsy.Semantic proximity Read ↗

ApoE epsilon4 allele and disease duration affect verbal learning in mild temporal lobe epilepsy.Semantic proximity Read ↗

GABA(B) receptor 1 polymorphism (G1465A) is associated with temporal lobe epilepsy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.