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Article

Age-dependent effects of the 5-hydroxytryptamine-2a-receptor polymorphism (His452Tyr) on human memory.

Neuroreport - 31 May 2005

Papassotiropoulos Andreas, Henke Katharina, Aerni Amanda, Coluccia Daniel, Garcia Esmeralda, Wollmer Marc A, Huynh Kim-Dung, Monsch Andreas U, Stähelin Hannes B, Hock Christoph, Nitsch Roger M, de Quervain Dominique J-F

Abstract excerpt

A polymorphism (His452Tyr) of the 5-hydroxytryptamine (5-HT)2a receptor is associated with episodic memory in healthy young humans. Because 5-HT2a-receptor density decreases with increasing age, we tested whether the 5-HT2a receptor genotype effect on memory is influenced by age. We investigated the association of the His452Tyr genotype with memory performance in 622 healthy study participants aged from 18 to 90...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15891581
DOI: 10.1097/00001756-200505310-00012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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