Article
Genome-wide linkage analyses of hereditary prostate cancer families with colon cancer provide further evidence for a susceptibility locus on 15q11-q14.
European journal of human genetics : EJHG - 1 Oct 2010
Fitzgerald Liesel M, McDonnell Shannon K, Carlson Erin E, Langeberg Wendy, McIntosh Laura M, Deutsch Kerry, Ostrander Elaine A, Schaid Daniel J, Stanford Janet L
Abstract excerpt
The search for susceptibility loci in hereditary prostate cancer (HPC) is challenging because of locus and disease heterogeneity. One approach to reduce disease heterogeneity is to stratify families on the basis of the occurrence of multiple cancer types. This method may increase the power for detecting susceptibility loci, including those with pleiotropic effects. We have completed a genome-wide SNP linkage...
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