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Automated Detection of Toxigenic Clostridium difficile in Clinical Samples: Isothermal <i>tcdB</i> Amplification Coupled to Array-Based Detection

7 Jun 2012

Abstract excerpt

Clostridium difficile can carry a genetically variable pathogenicity locus (PaLoc), which encodes clostridial toxins A and B. In hospitals and in the community at large, this organism is increasingly identified as a pathogen. To develop a diagnostic test that combines the strengths of immunoassays (cost) and DNA amplification assays (sensitivity/specificity), we targeted a genetically stable PaLoc region,...

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PMID: 22675134
DOI: 10.1128/jcm.00621-12

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