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Comparison of Real-Time PCR for Detection of the <i>tcdC</i> Gene with Four Toxin Immunoassays and Culture in Diagnosis of <i>Clostridium difficile</i> Infection

24 Apr 2008

Abstract excerpt

We have developed a rapid real-time PCR method using fluorescence resonance energy transfer probes and the LightCycler (Roche Diagnostics), which will detect the presence of the tcdC gene of Clostridium difficile in stool samples. Our PCR method also will identify the presence of base pair deletions, one of which (18 bp) has been associated with the "epidemic" toxin-hyperproducing strains. We compared the results...

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PMID: 18434563
DOI: 10.1128/jcm.00032-08

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