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Article

Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection

9 Mar 2011

Abstract excerpt

Human chromosome ends associate with shelterin, a six-protein complex that protects telomeric DNA from being recognized as sites of DNA damage. The shelterin subunit TRF2 has been implicated in the protection of chromosome ends by facilitating their organization into the protective capping structure and by associating with several accessory proteins involved in various DNA transactions. Here we describe the...

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PMID: 21388492
DOI: 10.1111/j.1474-9726.2011.00696.x

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