Article
Hedgehog signaling via a calcitonin receptor-like receptor can induce arterial differentiation independently of VEGF signaling in zebrafish.
Blood - 12 Jul 2012
Wilkinson Robert N, Koudijs Marco J, Patient Roger K, Ingham Philip W, Schulte-Merker Stefan, van Eeden Fredericus J M
Abstract excerpt
Multiple signaling pathways control the specification of endothelial cells (ECs) to become arteries or veins during vertebrate embryogenesis. Current models propose that a cascade of Hedgehog (Hh), vascular endothelial growth factor (VEGF), and Notch signaling acts instructively on ECs to control the choice between arterial or venous fate. Differences in the phenotypes induced by Hh, VEGF, or Notch inhibition...
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