Article
Notch signaling is required for arterial-venous differentiation during embryonic vascular development.
Development (Cambridge, England) - 1 Oct 2001
Lawson N D, Scheer N, Pham V N, Kim C H, Chitnis A B, Campos-Ortega J A, Weinstein B M
Abstract excerpt
Recent evidence indicates that acquisition of artery or vein identity during vascular development is governed, in part, by genetic mechanisms. The artery-specific expression of a number of Notch signaling genes in mouse and zebrafish suggests that this pathway may play a role in arterial-venous cell fate determination during vascular development. We show that loss of Notch signaling in zebrafish embryos leads to...
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