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Article

Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women.

Menopause (New York, N.Y.) - 1 Sept 2012

Xiao Wenjin, Ke Yaohua, He Jinwei, Zhang Hao, Yu Jinbo, Hu Weiwei, Gu Jiemei, Yue Hua, Wang Chun, Hu Yunqiu, Li Miao, Fu Wenzhen, Liu Yujuan, Zhang Zhenlin

Abstract excerpt

OBJECTIVE: Lipoxygenase (LOX) is one of the major metabolic enzymes for arachidonic acid, which has been reported to be associated with many postmenopausal and many hormone-related diseases. In rats, selective inhibition of the LOX pathway led to defective ovulation. However, little is known about the association of the LOX-related genes with menstruation in women. In this study, we investigated the possible...

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Source

Identifiers

PMID: 22668814
DOI: 10.1097/gme.0b013e31824e6160

Genes

ALOX12
ALOX15
LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association of ALOX12 and ALOX15 gene polymorphisms with age at menarche and natural menopause in Chinese women.PMID 22668814Read ↗

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Association analyses suggest the effects of RANK and RANKL on age at menarche in Chinese women.Semantic proximity Read ↗

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