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Article

Sex-specific association of sequence variants in CBS and MTRR with risk for promoter hypermethylation in the lung epithelium of smokers.

Carcinogenesis - 1 Aug 2012

Flores Kristina G, Stidley Christine A, Mackey Amanda J, Picchi Maria A, Stabler Sally P, Siegfried Jill M, Byers Tim, Berwick Marianne, Belinsky Steven A, Leng Shuguang

Abstract excerpt

Gene promoter hypermethylation is now regarded as a promising biomarker for the risk and progression of lung cancer. The one-carbon metabolism pathway is postulated to affect deoxyribonucleic acid (DNA) methylation because it is responsible for the generation of S-adenosylmethionine (SAM), the methyl donor for cellular methylation reactions. This study investigated the association of single nucleotide...

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Share to Cystathionine beta-Synthase
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Ferredoxin-NADP Reductase

Share to Polymorphism, Single Nucleotide

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 22665368
DOI: 10.1093/carcin/bgs194
PMCID: PMC3499054

Genes

CBS
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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