Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.

BMC medical genetics - 21 Nov 2011

Wernimont Susan M, Clark Andrew G, Stover Patrick J, Wells Martin T, Litonjua Augusto A, Weiss Scott T, Gaziano J Michael, Tucker Katherine L, Baccarelli Andrea, Schwartz Joel, Bollati Valentina, Cassano Patricia A

Abstract excerpt

BACKGROUND: Sequence variants in genes functioning in folate-mediated one-carbon metabolism are hypothesized to lead to changes in levels of homocysteine and DNA methylation, which, in turn, are associated with risk of cardiovascular disease. METHODS: 330 SNPs in 52 genes were studied in relation to plasma homocysteine and global genomic DNA methylation. SNPs were selected based on functional effects and gene...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alu Elements
Share to Aminohydrolases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Homocysteine

Share to Long Interspersed Nucleotide Elements

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

Share to Multienzyme Complexes

Share to Vitamin B 6

Source

Open in PubMed Open full text

Identifiers

PMID: 22103680
DOI: 10.1186/1471-2350-12-150
PMCID: PMC3266217

Genes

MTHFR
FTCD
SARDH

Variants

rs1801133

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.PMID 22103680Read ↗

Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.Semantic proximity Read ↗

Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.Semantic proximity Read ↗

Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.Semantic proximity Read ↗

Associations between Genetic Variants and Blood Biomarkers of One-Carbon Metabolism in Postmenopausal Women from the Women's Health Initiative Observational Study.Semantic proximity Read ↗

Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway.Semantic proximity Read ↗

MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A ReviewSemantic proximity Read ↗

The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway.Semantic proximity Read ↗

Examination of Genetic and Epigenetic Characteristics of Patients with Hyperhomocysteinemia Following High-Dose Folic Acid ConsumptionSemantic proximity Read ↗

The effect of multiple single nucleotide polymorphisms in the folic acid pathway genes on homocysteine metabolism.Semantic proximity Read ↗

Association of genetic and epigenetic variants in one-carbon metabolism gene with folate treatment response in hyperhomocysteinaemia.Semantic proximity Read ↗

MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical ImplicationsSemantic proximity Read ↗

Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.