Article
Human endonuclease V as a repair enzyme for DNA deamination.
Mutation research - 1 Jul 2012
Mi Rongjuan, Alford-Zappala Maria, Kow Yoke W, Cunningham Richard P, Cao Weiguo
Abstract excerpt
The human endonuclease V gene is located in chromosome 17q25.3 and encodes a 282 amino acid protein that shares about 30% sequence identity with bacterial endonuclease V. This study reports biochemical properties of human endonuclease V with respect to repair of deaminated base lesions. Using soluble proteins fused to thioredoxin at the N-terminus, we determined repair activities of human endonuclease V on...
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