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Article

Engineering novel restriction endonucleases: principles and applications.

Trends in biotechnology - 1 Jul 1996

Jeltsch A, Wenz C, Wende W, Selent U, Pingoud A

Abstract excerpt

Restriction endonucleases cleave DNA with remarkable sequence specificity. In this review, we summarize the status of, and prospects for, engineering restriction endonucleases with new specificities. Such variants could be of considerable commercial value because restriction enzymes are among the most frequently used enzymes in molecular biology, and not all the desirable specificities are available. While it has...

Read the complete abstract on PubMed

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
Biotechnology
DNA
DNA Restriction Enzymes
Metals

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

Protein Engineering

Substrate Specificity

Source

Identifiers

PMID: 8771796
DOI: 10.1016/0167-7799(96)10030-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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