Article
The excision of 3' penultimate errors by DNA polymerase I and its role in endonuclease V-mediated DNA repair.
DNA repair - 1 Nov 2013
Lee Chia-Chia, Yang Ya-Chien, Goodman Steven D, Lin Chien-Ju, Chen Yi-An, Wang Yi-Ting, Cheng Wern-Cherng, Lin Liang-In, Fang Woei-Horng
Abstract excerpt
Deamination of adenine can occur spontaneously under physiological conditions, and is enhanced by exposure of DNA to ionizing radiation, UV light, nitrous acid, or heat, generating the highly mutagenic lesion of deoxyinosine in DNA. Such DNA lesions tends to generate A:T to G:C transition mutations if unrepaired. In Escherichia coli, deoxyinosine is primarily removed through a repair pathway initiated by...
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