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Ribonucleotides and manganese ions improve non-homologous end joining by human Polµ

26 Dec 2012

Abstract excerpt

Human DNA polymerase mu (Polμ), a family X member involved in DNA repair, has both template-directed and terminal transferase (template-independent) activities. In addition to their ability to incorporate untemplated nucleotides, another similarity between Polµ and terminal deoxynucleotidyl transferase (TdT) is their promiscuity in using ribonucleotides (NTPs), whose physiological significance is presently...

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PMID: 23275568
DOI: 10.1093/nar/gks1444

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