Article
Isolation of cDNA clones encoding a human apurinic/apyrimidinic endonuclease that corrects DNA repair and mutagenesis defects in E. coli xth (exonuclease III) mutants.
Nucleic acids research - 25 Oct 1991
Robson C N, Hickson I D
Abstract excerpt
Apurinic/apyrimidinic (AP) sites in cellular DNA are considered to be both cytotoxic and mutagenic, and can arise spontaneously or following exposure to DNA damaging agents. We have isolated cDNA clones which encode an endonuclease, designated HAP1 (human AP endonuclease 1), that catalyses the in...
Topics
- Amino Acid Sequence
- Cloning, Molecular
- DNA
- DNA Repair
- DNA, Bacterial
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- Endodeoxyribonucleases
- Escherichia coli
- Escherichia coli Proteins
- Exodeoxyribonucleases
- Humans
- Hydrogen Peroxide
- Methyl Methanesulfonate
- Molecular Sequence Data
- Mutagenesis
- Mutation
- Sequence Alignment