Article
A P2RX7 single nucleotide polymorphism haplotype promotes exon 7 and 8 skipping and disrupts receptor function.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2020
Skarratt Kristen K, Gu Ben J, Lovelace Michael D, Milligan Carol J, Stokes Leanne, Glover Rachel, Petrou Steven, Wiley James S, Fuller Stephen J
Abstract excerpt
P2X7 is an ATP-gated membrane ion channel that is expressed by multiple cell types. Brief exposure to ATP induces the opening of a nonselective cation channel; while repeated or prolonged exposure induces formation of a transmembrane pore. This process may be partially regulated by alternative splicing of full-length P2RX7A pre-mRNA, producing isoforms that delete or retain functional domains. Here, we report...
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