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Article

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.

Human molecular genetics - 15 Aug 2006

Lucae Susanne, Salyakina Daria, Barden Nicholas, Harvey Mario, Gagné Bernard, Labbé Michel, Binder Elisabeth B, Uhr Manfred, Paez-Pereda Marcelo, Sillaber Inge, Ising Marcus, Brückl Tanja, Lieb Roselind, Holsboer Florian, Müller-Myhsok Bertram

Abstract excerpt

The P2RX7 gene is located within a region on chromosome 12q24.31 that has been identified as a susceptibility locus for affective disorders by linkage and association studies. P2RX7 is a purinergic ATP-binding calcium channel expressed in neurons as well as in microglial cells in various brain regions. We investigated 29 single nucleotide polymorphisms (SNPs) within the P2RX7 gene and adjacent genes in a sample...

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Identifiers

PMID: 16822851
DOI: 10.1093/hmg/ddl166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder.PMID 16822851Read ↗

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Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.Semantic proximity Read ↗

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