Article
Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11.
European heart journal - 1 Jan 2007
Amisten Stefan, Melander Olle, Wihlborg Anna-Karin, Berglund Göran, Erlinge David
Abstract excerpt
AIMS: Extracellular ATP acting on the P2Y11 receptor regulates inflammatory cells. We hypothesized that polymorphisms in the receptor could influence the risk of acute myocardial infarction (AMI). METHODS AND RESULTS: In the Malmö diet and cancer AMI case-control study (n = 3732) the P2Y11 gene Thr-87 polymorphism was present in 19.8% of the controls and 22.9% in AMI patients (OR 1.21; P = 0.03). Stronger...
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