A single nucleotide polymorphism in 3'-untranslated region contributes to the regulation of Toll-like receptor 4 translation.

doi:10.1074/jbc.M111.338426

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Article

A single nucleotide polymorphism in 3'-untranslated region contributes to the regulation of Toll-like receptor 4 translation.

The Journal of biological chemistry - 20 Jul 2012

Sato Kayo, Yoshimura Atsutoshi, Kaneko Takashi, Ukai Takashi, Ozaki Yukio, Nakamura Hirotaka, Li Xinyue, Matsumura Hiroyoshi, Hara Yoshitaka, Ogata Yorimasa

Abstract excerpt

We have previously shown that a single nucleotide polymorphism rs11536889 in the 3'-untranslated region (UTR) of TLR4 was associated with periodontitis. In this study the effects of this single nucleotide polymorphism on Toll-like receptor (TLR) 4 expression were investigated. Monocytes from subjects with the C/C genotype expressed higher levels of TLR4 on their surfaces than those from subjects with the other...

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PMID: 22661708
DOI: 10.1074/jbc.M111.338426
PMCID: PMC3408206

Genes

TLR4
CSK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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