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Article

Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human TLR-4 gene.

Genes and immunity - 1 Aug 2005

Schröder N W J, Meister D, Wolff V, Christan C, Kaner D, Haban V, Purucker P, Hermann C, Moter A, Göbel U B, Schumann R R

Abstract excerpt

Periodontitis is an inflammatory disease affecting the connective tissue surrounding the teeth leading to tooth loss. Pathogens associated with periodontitis interact with Toll-like receptors (TLRs) to induce cytokines causing and aggravating disease. We screened 197 individuals suffering from generalized periodontitis for the presence of Asp299Gly and Thr399Ile of TLR-4 as well as Arg753Gln of TLR-2 in...

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Source

Identifiers

PMID: 15875057
DOI: 10.1038/sj.gene.6364221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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