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Article

Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis.

Journal of clinical periodontology - 1 Feb 2007

James Jacqueline A, Poulton Kay V, Haworth Simone E, Payne Debbie, McKay Ian J, Clarke Fiona M, Hughes Francis J, Linden Gerard J

Abstract excerpt

OBJECTIVE: To study whether there is an association between the frequency of functional polymorphisms in the toll-like receptor 4 (TLR4) and cluster differentiation 14 (CD14) genes and periodontitis. METHODOLOGY: Genotyping for the TLR4 single-nucleotide polymorphisms (SNPs) Asp299Gly, Thr399Ile and the CD14 SNPs -159 and -1359 was completed for subjects with periodontal disease compared with control subjects....

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Source

Identifiers

PMID: 17309585
DOI: 10.1111/j.1600-051X.2006.01030.x

Genes

TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Polymorphisms of TLR4 but not CD14 are associated with a decreased risk of aggressive periodontitis.PMID 17309585Read ↗

Single nucleotide polymorphisms of pattern recognition receptors and chronic periodontitis.Semantic proximity Read ↗

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The CD14 rs2569190 TT Genotype is Associated with Chronic Periodontitis.Semantic proximity Read ↗

CD14 and TLR4 gene polymorphisms in adult periodontitis.Semantic proximity Read ↗

TLR4 as a risk factor for periodontal disease: a reappraisal.Semantic proximity Read ↗

Polymorphisms of Toll-Like Receptor 4 as a Risk Factor for Periodontitis: Meta-Analysis.Semantic proximity Read ↗

Genetic polymorphisms in pattern recognition receptors and risk of periodontitis: Evidence based on 12,793 subjects.Semantic proximity Read ↗

Impact of genetic variants of CD14 and TLR4 on subgingival periodontopathogens.Semantic proximity Read ↗

Association of the -159 CD14 gene polymorphism and lack of association of the -308 TNFA and Q551R IL-4RA polymorphisms with severe chronic periodontitis in Swedish Caucasians.Semantic proximity Read ↗

TLR4 Asp299Gly polymorphism may be protective against chronic periodontitis.Semantic proximity Read ↗

Polymorphism of CD14 Gene Is Associated with Adverse Outcome among Patients Suffering from Cardiovascular Disease.Semantic proximity Read ↗

TLR2 Arg753Gly, TLR4 Asp299Gly and Thr399Ile gene polymorphisms are not associated with chronic periodontitis in a Turkish population.Semantic proximity Read ↗

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