Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional characterization of a single nucleotide polymorphism in the 5' UTR region of the bovine toll-like receptor 4 gene.

Developments in biologicals - 1 Jan 2008

Sharma B S, Mount J, Karrow N A

Abstract excerpt

Toll-like receptor 4 (TLR4) is the key receptor for the LPS component of Gram-negative bacteria. We have identified a SNP within the 5' UTR region of the bovine TLR4 gene at position 226 (c.-226C>G) relative to start codon, which was found to be associated with health related traits in the Canadian Holstein population. TLR4 gene expression was measured over time intervals in samples collected from 18 cows (6 cows...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5' Untranslated Regions
Share to Base Sequence
Share to Cattle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to TLR4 gene

Share to Polymerase Chain Reaction

Share to Polymorphism, Single Nucleotide

Share to Toll-Like Receptor 4

Source

Identifiers

PMID: 18817322
DOI: 10.1159/000317179

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional characterization of a single nucleotide polymorphism in the 5' UTR region of the bovine toll-like receptor 4 gene.PMID 18817322Read ↗

Identification of single nucleotide polymorphisms in the bovine Toll-like receptor 1 gene and association with health traits in cattle.Semantic proximity Read ↗

Single Nucleotide Polymorphisms in 5' Upstream Region of Bovine TLR4 Gene Affecting Expression Profile and Transcription Factor Binding Sites.Semantic proximity Read ↗

Analysis of sequence variability and protein domain architectures for bovine peptidoglycan recognition protein 1 and Toll-like receptors 2 and 6.Semantic proximity Read ↗

Contribution of the mutation rs8193069 in TLR4 to mastitis resistance and performance in Holstein cows in southern China.Semantic proximity Read ↗

SNP Analysis of TLR4 Promoter and Its Transcriptional Factor Binding Profile in Relevance to Bovine Subclinical Mastitis.Semantic proximity Read ↗

Toll-like receptor 4 (TLR4) polymorphisms in ruminants: A review of genetic associations with health, reproduction, and production traits.Semantic proximity Read ↗

Haplotype variation in bovine Toll-like receptor 4 and computational prediction of a positively selected ligand-binding domain.Semantic proximity Read ↗

Variation in the Toll-like Receptor 4 (TLR4) gene affects milk traits in dairy cows.Semantic proximity Read ↗

DNA methylation rather than single nucleotide polymorphisms regulates the production of an aberrant splice variant of IL6R in mastitic cows.Semantic proximity Read ↗

Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10.Semantic proximity Read ↗

Sequence variability and protein domain architectures for bovine Toll-like receptors 1, 5, and 10.Semantic proximity Read ↗

Single nucleotide polymorphisms alter the promoter activity of bovine MIF.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.