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Article

Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight.

PloS one - 1 Jan 2012

Penas-Steinhardt Alberto, Barcos Lucía Soledad, Belforte Fiorella Sabrina, de Sereday Martha, Vilariño Jorge, Gonzalez Claudio Daniel, Martínez-Larrad María Teresa, Tellechea Mariana Lorena, Serrano-Ríos Manuel, Poskus Edgardo, Frechtel Gustavo Daniel, Leskow Federico Coluccio

Abstract excerpt

Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation. W...

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Identifiers

PMID: 23239997
DOI: 10.1371/journal.pone.0050992
PMCID: PMC3519812

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23239997-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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