Article
3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).
Journal of chemical information and modeling - 23 Jul 2012
Tan Jun, Abrol Ravinder, Trzaskowski Bartosz, Goddard William A
Abstract excerpt
The G protein-coupled receptor (GPCR) TAS2R38 is a bitter taste receptor that can respond to bitter compounds such as phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP). This receptor was chosen because its four haplotypes (based on three residue site polymorphism) hTAS2R38PAV, hTAS2R38AVI, hTAS2R38AAI, and hTAS2R38PVV are known to have dramatically different responses to PTC and PROP. We aimed to identify...
Topics
- Amino Acid Sequence
- Genetic Variation
- Humans
- Hydrogen Bonding
- Models, Biological
- Molecular Structure
- Monte Carlo Method
- Phenylthiourea
- Propylthiouracil
- Receptors, G-Protein-Coupled