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Article

Differential Activation of TAS2R4 May Recover Ability to Taste Propylthiouracil for Some TAS2R38 AVI Homozygotes.

Nutrients - 30 Apr 2024

Nolden Alissa A, Behrens Maik, McGeary John E, Meyerhof Wolfgang, Hayes John E

Abstract excerpt

Bitterness from phenylthiocarbamide and 6-n-propylthiouracil (PROP) varies with polymorphisms in the TAS2R38 gene. Three SNPs form two common (AVI, PAV) and four rare haplotypes (AAI, AAV, PVI, and PAI). AVI homozygotes exhibit higher detection thresholds and lower suprathreshold bitterness for P...

Topics

Adult
Female
Humans
Male
Young Adult
Haplotypes
Homozygote
Polymorphism, Single Nucleotide
Propylthiouracil
Receptors, G-Protein-Coupled
Taste
Taste Threshold

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Taste Receptors, Type 2

Source

Open in PubMed Open full text

Identifiers

PMID: 38732607
DOI: 10.3390/nu16091357
PMCID: PMC11085076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38732607-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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