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Article

The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception.

Current biology : CB - 22 Feb 2005

Bufe Bernd, Breslin Paul A S, Kuhn Christina, Reed Danielle R, Tharp Christopher D, Slack Jay P, Kim Un-Kyung, Drayna Dennis, Meyerhof Wolfgang

Abstract excerpt

Individual differences in perception are ubiquitous within the chemical senses: taste, smell, and chemical somesthesis . A hypothesis of this fact states that polymorphisms in human sensory receptor genes could alter perception by coding for functionally distinct receptor types . We have previously reported evidence that sequence variants in a presumptive bitter receptor gene (hTAS2R38) correlate with differences...

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Identifiers

PMID: 15723792
DOI: 10.1016/j.cub.2005.01.047
PMCID: PMC1400547

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception.PMID 15723792Read ↗

Variability in Human Bitter Taste Sensitivity to Chemically Diverse Compounds Can Be Accounted for by Differential TAS2R Activation.Semantic proximity Read ↗

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Supertasting and PROP bitterness depends on more than the TAS2R38 gene.Semantic proximity Read ↗

Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells.Semantic proximity Read ↗

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