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Article

Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population.

Neuroscience letters - 26 Mar 2010

Shiroiwa Kyoichi, Hishimoto Akitoyo, Mouri Kentaro, Fukutake Masaaki, Supriyanto Irwan, Nishiguchi Naoki, Shirakawa Osamu

Abstract excerpt

Alteration of serotonin transmission in the brain of patients with schizophrenia has been reported in postmortem brain studies, cerebrospinal fluid studies, and pharmacological challenges. Although a genetic association of tryptophan hydroxylase isoform 1 (TPH1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal...

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Source

Identifiers

PMID: 20144688
DOI: 10.1016/j.neulet.2010.02.003

Genes

TPH2
TPH1

Variants

rs1800532

Provenance

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Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population.PMID 20144688Read ↗

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