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Article

Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.

Molecular cell - 4 Mar 2011

Zhang Xuxiao, Vadas Oscar, Perisic Olga, Anderson Karen E, Clark Jonathan, Hawkins Phillip T, Stephens Len R, Williams Roger L

Abstract excerpt

Phosphoinositide 3-kinases (PI3Ks) are essential for cell growth, migration, and survival. The structure of a p110β/p85β complex identifies an inhibitory function for the C-terminal SH2 domain (cSH2) of the p85 regulatory subunit. Mutagenesis of a cSH2 contact residue activates downstream signaling in cells. This inhibitory contact ties up the C-terminal region of the p110β catalytic subunit, which is essential...

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Identifiers

PMID: 21362552
DOI: 10.1016/j.molcel.2011.01.026
PMCID: PMC3670040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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