Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk.

Journal of molecular biology - 20 Jun 2003

Laederach Alain, Cradic Kendall W, Fulton D Bruce, Andreotti Amy H

Abstract excerpt

A protein fragment from the Tec family member Rlk (also known as Txk) containing a single proline-rich ligand adjacent to a Src homology 3 (SH3) domain has been investigated by nuclear magnetic resonance (NMR) spectroscopy. Analysis of the concentration dependence of the chemical shifts, NMR linewidths and self-diffusion coefficients reveal that the Rlk fragment dimerizes in solution. Mutation of two critical...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Magnetic Resonance Spectroscopy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proline

Share to Protein Conformation

Share to Protein Structure, Tertiary

Share to Protein-Tyrosine Kinases

Share to Sequence Homology, Amino Acid

Share to src Homology Domains

Source

Identifiers

PMID: 12798690
DOI: 10.1016/s0022-2836(03)00531-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Determinants of intra versus intermolecular self-association within the regulatory domains of Rlk and Itk.PMID 12798690Read ↗

<i>In Vivo</i>Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell KinaseSemantic proximity Read ↗

Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization.Semantic proximity Read ↗

Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6.Semantic proximity Read ↗

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.Semantic proximity Read ↗

A proline to glycine mutation in the Lck SH3-domain affects conformational sampling and increases ligand binding affinity.Semantic proximity Read ↗

Activation of the Src family kinase Hck without SH3-linker release.Semantic proximity Read ↗

Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures.Semantic proximity Read ↗

Endogenous tryptophan residues of cAPK regulatory subunit type IIbeta reveal local variations in environments and dynamics.Semantic proximity Read ↗

Chaperone-like effect of the linker on the isolated C-terminal domain of rabbit muscle creatine kinase.Semantic proximity Read ↗

Genetically Encoded Förster Resonance Energy Transfer Sensors for the Conformation of the Src Family Kinase LckSemantic proximity Read ↗

Lipid-driven Src self-association modulates its transformation capacity.Semantic proximity Read ↗

An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.