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Article

Role of the autophosphorylation site on the biological function of pp56lck.

Oncogene - 15 Jun 1995

Carrera A C, Borlado L R, Gonzalez-Garcia A, Roberts T M, Martinez C

Abstract excerpt

Src-family tyrosine kinases act as signaling molecules in a wide array of cellular activation processes. The existence of the various src-family members reflects the requirement for different cell-surface receptors to transmit cell-type specific intracellular signals. The structural basis for the...

Topics

Base Sequence
Cells, Cultured
Chloramphenicol O-Acetyltransferase
Humans
Interleukin-2
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Lymphocytes
Molecular Sequence Data
Mutation
Phosphorylation
Protein-Tyrosine Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Fusion Proteins

Substrate Specificity

Source

Identifiers

PMID: 7784086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7784086-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Role of the autophosphorylation site on the biological function of pp56lck.PMID 7784086Read ↗

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.Semantic proximity Read ↗

Regulation of the oncogenic activity of the cellular src protein requires the correct spacing between the kinase domain and the C-terminal phosphorylated tyrosine (Tyr-527).Semantic proximity Read ↗

The role of competing mechanisms on Lck regulation.Semantic proximity Read ↗

Proteomic Analysis of Src Family Kinase Phosphorylation States in Cancer Cells Suggests Deregulation of the Unique Domain.Semantic proximity Read ↗

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.Semantic proximity Read ↗

Role of the Src homology 2 domains and interdomain regions in ZAP-70 phosphorylation and enzymatic activity.Semantic proximity Read ↗

<i>In Vivo</i>Consequences of Disrupting SH3-Mediated Interactions of the Inducible T-Cell KinaseSemantic proximity Read ↗

The SH2 domain is required for stable phosphorylation of p56lck at tyrosine 505, the negative regulatory site.Semantic proximity Read ↗

Evidence of autophosphorylation in Txk: Y91 is an autophosphorylation site.Semantic proximity Read ↗

Functional hierarchy of the N-terminal tyrosines of SLP-76.Semantic proximity Read ↗

The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection.Semantic proximity Read ↗

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.Semantic proximity Read ↗

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