Article
Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.
The Journal of biological chemistry - 8 Mar 2013
Hussain Alamdar, Mohammad Dara K, Gustafsson Manuela O, Uslu Merve, Hamasy Abdulrahman, Nore Beston F, Mohamed Abdalla J, Smith C I Edvard
Abstract excerpt
The inducible T cell kinase-spleen tyrosine kinase (ITK-SYK) oncogene consists of the Tec homology-pleckstrin homology domain of ITK and the kinase domain of SYK, and it is believed to be the cause of peripheral T cell lymphoma. We and others have recently demonstrated that this fusion protein is constitutively tyrosine-phosphorylated and is transforming both in vitro and in vivo. To gain a deeper insight into...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.