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Article

Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Journal of molecular biology - 22 Feb 2013

Xie Qian, Joseph Raji E, Fulton D Bruce, Andreotti Amy H

Abstract excerpt

Itk (interleukin-2 inducible T cell kinase) is a non-receptor protein tyrosine kinase expressed primarily in T cells. Itk catalyzes phosphorylation on tyrosine residues within a number of its natural substrates, including the well-characterized Y783 of PLCγ1. However, the molecular mechanisms Itk exploits to recognize its substrates are not completely understood. We have previously identified a specific docking...

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Identifiers

PMID: 23219468
DOI: 10.1016/j.jmb.2012.10.023
PMCID: PMC3880187

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