Article
A fine-mapping study of 7 top scoring genes from a GWAS for major depressive disorder.
PloS one - 1 Jan 2012
Verbeek Eva C, Bakker Ingrid M C, Bevova Marianna R, Bochdanovits Zoltán, Rizzu Patrizia, Sondervan David, Willemsen Gonneke, de Geus Eco J, Smit Johannes H, Penninx Brenda W, Boomsma Dorret I, Hoogendijk Witte J G, Heutink Peter
Abstract excerpt
Major depressive disorder (MDD) is a psychiatric disorder that is characterized--amongst others--by persistent depressed mood, loss of interest and pleasure and psychomotor retardation. Environmental circumstances have proven to influence the aetiology of the disease, but MDD also has an estimated 40% heritability, probably with a polygenic background. In 2009, a genome wide association study (GWAS) was performed...
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