Article
Genome-wide association studies on Northern Italy isolated populations provide further support concerning genetic susceptibility for major depressive disorder.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Feb 2023
Dattilo Vincenzo, Ulivi Sheila, Minelli Alessandra, La Bianca Martina, Giacopuzzi Edoardo, Bortolomasi Marco, Bignotti Stefano, Gennarelli Massimo, Gasparini Paolo, Concas Maria Pina
Abstract excerpt
OBJECTIVES: Major depressive disorder (MDD) is a psychiatric disorder with pathogenesis influenced by both genetic and environmental factors. To date, the molecular-level understanding of its aetiology remains unclear. Thus, we aimed to identify genetic variants and susceptibility genes for MDD with a genome-wide association study (GWAS) approach. METHODS: We performed a meta-analysis of GWASs and a gene-based...
Topics
- Humans
- Depressive Disorder, Major
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Multifactorial Inheritance
- Italy
- Polymorphism, Single Nucleotide