Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Divergent functions through alternative splicing: the Drosophila CRMP gene in pyrimidine metabolism, brain, and behavior.

Genetics - 1 Aug 2012

Morris Deanna H, Dubnau Josh, Park Jae H, Rawls John M

Abstract excerpt

DHP and CRMP proteins comprise a family of structurally similar proteins that perform divergent functions, DHP in pyrimidine catabolism in most organisms and CRMP in neuronal dynamics in animals. In vertebrates, one DHP and five CRMP proteins are products of six genes; however, Drosophila melanogaster has a single CRMP gene that encodes one DHP and one CRMP protein through tissue-specific, alternative splicing of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amidohydrolases
Share to Circadian Rhythm
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fertility

Share to Gene Order

Share to Memory

Share to Morphogenesis

Share to Pyrimidines

Source

Open in PubMed Open full text

Identifiers

PMID: 22649077
DOI: 10.1534/genetics.112.141101
PMCID: PMC3416003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Divergent functions through alternative splicing: the Drosophila CRMP gene in pyrimidine metabolism, brain, and behavior.PMID 22649077Read ↗

The study of differential expressions of MCPH and Seckel syndrome genes and their paraloguesSemantic proximity Read ↗

Individual carboxypeptidase D domains have both redundant and unique functions in Drosophila development and behavior.Semantic proximity Read ↗

Organization of the Rab-GDI/CHM superfamily: the functional basis for choroideremia disease.Semantic proximity Read ↗

Rewiring protein binding specificity in paralogous DRG/DFRP complexes.Semantic proximity Read ↗

The conserved alternative splicing factor caper regulates neuromuscular phenotypes during development and aging.Semantic proximity Read ↗

Drosophila polypyrimidine tract-binding protein (DmPTB) regulates dorso-ventral patterning genes in embryos.Semantic proximity Read ↗

Regulation of Drosophila brain development and organ growth by the Minibrain/Rala signaling network.Semantic proximity Read ↗

Cloning and characterization of the Caenorhabditis elegans CeCRMP/DHP-1 and -2; common ancestors of CRMP and dihydropyrimidinase?Semantic proximity Read ↗

Vertebrate paralogous CRMPs in nervous system: evolutionary, structural, and functional interplay.Semantic proximity Read ↗

Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein.Semantic proximity Read ↗

Rewiring protein binding specificity in paralogous DRG/DFRP complexesSemantic proximity Read ↗

The functional effect of pathogenic mutations in Rab escort protein 1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.