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Article

Mutations in RRM4 uncouple the splicing repression and RNA-binding activities of polypyrimidine tract binding protein.

RNA (New York, N.Y.) - 1 Feb 2002

Liu Haiying, Zhang Wenqing, Reed Robyn B, Liu Weiqun, Grabowski Paula J

Abstract excerpt

The polypyrimidine tract binding protein (PTB, or hnRNP I) contains four RNA-binding domains of the ribonucleoprotein fold type (RRMs 1, 2, 3, and 4), and mediates the negative regulation of alternative splicing through sequence-specific binding to intronic splicing repressor elements. To assess the roles of individual RRM domains in splicing repression, a neural-specific splicing extract was used to screen for...

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Identifiers

PMID: 11911361
DOI: 10.1017/s1355838202015029
PMCID: PMC1370238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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