Article

Rewiring protein binding specificity in paralogous DRG/DFRP complexes

2023-06-02

Abstract excerpt

<h4>Summary</h4> The Developmentally Regulated GTP-binding (DRG) proteins are an ancient subfamily of GTPases implicated in the regulation of translation and cell growth. In eukaryotes, there are two paralogs: DRG1 and DRG2, both of which have a conserved binding partner called DRG family regulatory protein 1 and 2 (DFRP1 and DFRP2), respectively. These binding partners are required for the function of DRGs, incl...

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Literature Corpus work: 773d6290-e1e9-5921-b20a-2ccd1d33e69b
DOI: 10.1101/2023.05.31.543024

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