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Article

Rewiring protein binding specificity in paralogous DRG/DFRP complexes.

Structure (London, England : 1993) - 7 Nov 2024

Westrip Christian A E, Smerdon Stephen J, Coleman Mathew L

Abstract excerpt

Eukaryotes have two paralogous developmentally regulated GTP-binding (DRG) proteins: DRG1 and DRG2, both of which have a conserved binding partner called DRG family regulatory protein 1 and 2 (DFRP1 and DFRP2), respectively. DFRPs are important for the function of DRGs and interact with their respective DRG via a conserved region called the DFRP domain. Despite being highly similar, DRG1 and DRG2 have strict...

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PMID: 39276770
DOI: 10.1016/j.str.2024.08.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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