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Article

Dihydrofolate Reductase Gene Variations in Susceptibility to Disease and Treatment Outcomes

16 Nov 2010

Abstract excerpt

Dihydrofolate reductase (DHFR) catalyzes the reduction of dihydrofolate to tetrahydrofolate (THF). THF is needed for the action of folate-dependent enzymes and is thus essential for DNA synthesis and methylation. The importance of this reaction is demonstrated by the effectiveness of antifolate medications used to treat cancer by inhibiting DHFR, thereby depleting THF and slowing DNA synthesis and cell...

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PMID: 21629435
DOI: 10.2174/138920210793360925

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