Article
Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis.
Journal of biomedical science - 30 May 2012
Chen Tsung-Chieh, Wu José Jiun-Shian, Chang Wei-Pang, Hsu Ping-Ning, Hsieh Sung-Tsang, Shyu Bai-Chuang
Abstract excerpt
BACKGROUND: N-ethyl-N-nitrosourea mutagenesis was used to induce a point mutation in C57BL/6 J mice. Pain-related phenotype screening was performed in 915 G3 mice. We report the detection of a heritable recessive mutant in meiotic recombinant N1F1 mice that caused an abnormal pain sensitivity phe...
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