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Article

Investigation of TRPV1 loss-of-function phenotypes in TRPV1 Leu206Stop mice generated by N-ethyl-N-nitrosourea mutagenesis.

Biochemical and biophysical research communications - 2 Jun 2018

Christoph Thomas, Kögel Babette, Schiene Klaus, Peters Thomas, Schröder Wolfgang

Abstract excerpt

N-ethyl-N-nitrosourea (ENU) random mutagenesis was used to generate a mouse model for the analysis of the transient receptor potential vanilloid 1 (TRPV1) cation channel. A transversion from T→A in exon 4 led to a Leu206Stop mutation generating a loss-of-function mutant. The TRPV1 agonist capsaicin was used to analyze functional and nociceptive parameters in vitro and in vivo in TRPV1 Leu206Stop mice and congenic...

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Identifiers

PMID: 29660342
DOI: 10.1016/j.bbrc.2018.04.102

Genes

TRPV1

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