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Article

Signaling active CD95 receptor molecules trigger co-translocation of inactive CD95 molecules into lipid rafts.

The Journal of biological chemistry - 6 Jul 2012

Lang Isabell, Fick Andrea, Schäfer Viktoria, Giner Tina, Siegmund Daniela, Wajant Harald

Abstract excerpt

The capability of soluble CD95L trimers to trigger CD95-associated signaling pathways is drastically increased by oligomerization. The latter can be achieved, for example, by antibodies recognizing a N-terminal epitope tag in recombinant CD95L variants or by genetic engineering-enforced formation of hexamers. Using highly sensitive and accurate binding studies with recombinant CD95L variants equipped with a...

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Identifiers

PMID: 22645131
DOI: 10.1074/jbc.M111.328211
PMCID: PMC3390677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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