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Article

Matrix-dependent perturbation of TGFβ signaling and disease.

FEBS letters - 4 Jul 2012

Doyle Jefferson J, Gerber Elizabeth E, Dietz Harry C

Abstract excerpt

Transforming growth factor beta (TGFβ) is a multipotent cytokine that is sequestered in the extracellular matrix (ECM) through interactions with a number of ECM proteins. The ECM serves to concentrate latent TGFβ at sites of intended function, to influence the bioavailability and/or function of TGFβ activators, and perhaps to regulate the intrinsic performance of cell surface effectors of TGFβ signal propagation....

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Identifiers

PMID: 22641039
DOI: 10.1016/j.febslet.2012.05.027
PMCID: PMC3426037

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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