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Article

Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment

12 Oct 2021

Abstract excerpt

Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early stage tumorigenesis and promotes late stage tumor progression and metastasis. Here, we review the roles of TGF-β as well as components of its signaling pathways in tumorigenesis. We will discuss how a core property of TGF-β, namely its...

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PMID: 34712672
DOI: 10.3389/fcell.2021.764727

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