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TGF-β signaling in health and disease

1 Sept 2023

Abstract excerpt

The TGF-β regulatory system plays crucial roles in the preservation of organismal integrity. TGF-β signaling controls metazoan embryo development, tissue homeostasis, and injury repair through coordinated effects on cell proliferation, phenotypic plasticity, migration, metabolic adaptation, and immune surveillance of multiple cell types in shared ecosystems. Defects of TGF-β signaling, particularly in epithelial...

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PMID: 37714133
DOI: 10.1016/j.cell.2023.07.036

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