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Article

Cell mutants defective in synthesizing a heparan sulfate proteoglycan with regions of defined monosaccharide sequence.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 1990

De Agostini A L, Lau H K, Leone C, Youssoufian H, Rosenberg R D

Abstract excerpt

We have demonstrated that mouse LTA cells synthesize cell-surface heparan sulfate proteoglycans (HSPGs) with regions of defined monosaccharide sequence that specifically interact with antithrombin (HSPGact). It remains unclear how HSPGact can be generated by a biosynthetic pathway with no simple template for directing the ordered assembly of monosaccharide units. To examine this issue, we treated LTA cells with...

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Identifiers

PMID: 2263629
DOI: 10.1073/pnas.87.24.9784
PMCID: PMC55258

Genes

LTA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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